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KMID : 1137820130340030111
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의공학회지
2013 Volume.34 No. 3 p.111 ~ p.116
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A Study on Effects of EGCG and Design Parameter for Drug-Eluting Biodegradable Polymer Stents
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Jung Tae-Gon
Lee Jong-Ho
Lee J.-J
Hyon S.-H
Han Dong-Wook
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Abstract
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Finite element analysis(FEA) has been extensively applied in the analyses of biomechanical properties of stents. Geometrically, a closed-cell stent is an assembly of a number of repeated unit cells and exhibits periodicity in both longitudinal and circumferential directions. This study concentrates on various parameters of the FEA models for the analysis of drug-eluting biodegradable polymeric stents for application to the treatment of coronary artery disease. In order to determine the mechanical characteristics of biodegradable polymeric stents, FEA was used to model two different types of stents: tubular stents(TS) and helicoidal stents(HS). For this modeling, epigallocatechin-3-O-gallate (EGCG)-eluting poly[(L-lactide-co--caprolactone), PLCL] (E-PLCL) was chosen as drug-eluting stent materials. E-PLCL was prepared by blending PLCL with 5% EGCG as previously described. In addition, the effects of EGCG blending on the mechanical properties of PLCL were investigated for both types of stent models. EGCG did not affect tensile strength at break, but significantly increased elastic modulus of PLCL. It is suggested that FEA is a cost-effective method to improve the design of drug-eluting biodegradable polymeric stents.
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KEYWORD
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poly(L-lactide-co--caprolactone), epigallocatechin-3-O-gallate, finite element analysis, bio-degradable polymer stent, coronary artery disease
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